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KMID : 0923620110110060428
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Immune Network
2011 Volume.11 No. 6 p.428 ~ p.430
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Anti-CD137 mAb Deletes Both Donor CD4＋ and CD8＋ T Cells in Acute Graft-versus-host Disease
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Kim Ju-Yang
Cho Hong-Rae
Kwon Byung-Suk
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Abstract
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We previously demonstrated that in vivo engagement of CD137, a member of TNF receptor superfamily, can delete allorective CD4＋ T cells through the induction of activation-induced cell death (AICD) in chronic graft-versus-host disease (cGVHD) and subsequently reverse established cGVHD. In this study, we further showed that agonistic anti-CD137 mAb was highly effective in triggering AICD of donor CD8＋ T cells as well as donor CD4＋ T cells in the C57BL/6→unirradiated (C57BL/6 × DBA/2)F1 acute GVHD model. Our results suggest that strong allostimulation should facilitate AICD of both alloreactive CD4＋ and CD8＋ T cells induced by CD137 stimulation. Therefore, depletion of pathogenic T cells using agonistic anti-CD137 mAb combined with potent TCR stimulation may be used to block autoimmune or inflammatory diseases mediated by T cells.
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KEYWORD
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Rodent, T cells, Graft versus host disease, Costimulation
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